Dr. Rongxue Wu's Research Lab


Peer Reviewed Publications

  1. Wu RX, Gao L, Rao X: Pathological observation of the experimental cirrhosis of mice liver after administration with “anti-fibrosis No1”: Song Y, ed. Theory and Practice of Chinese Current Medicine. Beijing Science and Technology press; 1997: 823-829
  2. Wu RX, Gao L, Tian X: Study of “anti-fibrosis No 1” on liver cirrhosis. Combination of TCM and Western Medicine.1998, 348, 23-30.
  3. Tang B, Duan J, Wu H, Wu R, Niu Y: One case report of HELLP syndrome complicated with acute renal failure. 2001, Chin J Hepatol. July (9) 33
  4. Yang WB, Zhang YM, Wu RX: Clinical observation on the therapeutic effect of ribavirin on adult with measles. China tropical medicine. Sep; 1(3) 224-225
  5. You J, Zhuang L, Tang BZ, Yang WB, Ding SY, Li W, Wu RX, Zhang HL, Zhang YM, Yan SM, Zhang L: A randomized controlled clinical trial on the treatment of Thymosin a1 versus interferon-alpha in patients with hepatitis B. World J Gastroenterol 2001, 7(3):411-414
  6. Dai H, Wu R, Wang J, Ma S: One case report of allergic shock induced by the treatment of Nitrendipine Chinese Clinic New Medicine.  2002, 9 (2) 650
  7. Xiao Q, Wu R, Niu Y, Gu X: Psychological treatment of chronic hepatitis. The Journal of Chinese Medicine. 2002 April; 1:81-82
  8. You J, Zhuang L, Cheng HY, Yan SM, qiao YW, Huang JH, Tang BZ, Ma YL, Wu GB, Qu JY, Wu RX: A randomized, controlled, clinical study of thymosin alpha-1 versus interferon-alpha in patients with chronic hepatitis B lacking HBeAg in China. J Chin Med Assoc 2005, 68(2): 65-72
  9. Varadarajulu J, Laser M, Hupp M, Wu R, Hauck CR: Targeting of alpha(v) integrins interferes with FAK activation and smooth muscle cell migration and invasion. Biochem Biophys Res Commun 2005. 331(2): 404-12
  10. Wu RX, Laser M, Han H, Varadarajulu J, Schuh K, Hallhuber M, Hu K, Ertl G, Hauck CR, Ritter O: Fibroblast migration after myocardial infarction is regulated by transient SPARC expression. J Mol Med 2006, 84(3):241-252
  11. Hallhuber M, Burkard N, Wu R, Buch MH, Engelhardt S, Hein L, Neyses L, Schuh K, Ritter O: Inhibition of nuclear import of calcineurin prevents myocardial hypertrophy. Circ Res 2006, 99(6):626-635
  12. You J, Zhuang L, Cheng HY, Yan SM, Yu L, Huang JH, Tang BZ, Huang ML, Ma YL, Chongsuvivatwong V, Sriplung H, Geater A, Qiao YW, Wu RX: Efficacy of thymosin alpha-1 and interferon alpha in treatment of chronic viral hepatitis B: a randomized controlled study. World J Gastroenterol 2006, 12(41):6715-6721
  13. Burkard N, Rokita AG, Kaufmann SG, Hallhuber M, Wu R, Hu K, Hofmann U, Bonz A, Frantz S, Cartwright EJ, Neyse L, Maier LS, Maier SK, Renne T, Schuh K, Ritter O: Conditional neuronal nitric oxide synthase overexpression impairs myocardial contractility. Circ Res 2007, 100(3): e32-44
  14. Wyatt E, Wu R, Rabeh W, Park HW, Ghanefar M, Ardehali H: Regulation and cytoprotective role of hexokinase III. PLoS One 2010, 5(11): e13823
  15. Wu R, Smeele KM, Wyatt E, Ichikawa Y, Eerbeek O, Sun L, Chawla K, Hollmann MW, Nagpal V, Heikkinen S, Laakso M, Jujo K, Wasserstrom JA, Zuurbier CJ, Ardehali H: Reduction in Hexokinase II Levels Results in Decreased Cardiac Function and Altered Remodeling after Ischemia/Reperfusion injury. Circ Res. 2011, 108(1):60-69 (Featured article selected by editors on the cover and downloaded in the top tier for November 2011)
  16. Smeele KM, Southworth R, Wu R, xie C, Nederlof R, Warley A, Nelson JK, van Horssen P, van den Wijingaard JP, Heikkinen S, Laakso M, Koeman A, Siebes M, Eerbeek O. Akar FG, Ardehali H, Hollmann MW, Zuurbier CJ: Disruption of hexokinase II-mitochondrial binding blocks ischemic preconditioning and causes rapid cardiac necrosis. Circ Res 2011, 108(10): 1165-1169
  17. Arias-Loza PA., Hu K, Frantz S, Dienesch C, Bayer B, Wu R, Ertl G, Pelzer T. (2011) Medroxyprogesterone Acetate Aggravates Oxidative Stress and left Ventrucular Dysfunction in Rats with Chronic Myocardial infarction. Toxicologic Pathology. June 13
  18. Wu RX, Wyatt E, Chawla K, Tran M, Ghanefar M, Laakso M, Epting CL, Ardehali H: Hexokinase II knockdown results in exaggerated cardiac hypertrophy via increased ROS production. 2012, EMBO Mol Med. 2012 Apr 20.
  19. Ichikawa Y, Bayeva M, Ghanefar M, Potini V, Sun L, Mutharasan K, Wu RX, Ardehali H: Disruption of ATP-binding cassette B8 in mice leads to cardiomyopathy through a decrease in mitochondrial iron export. PNAS U S A. 2012 Mar 13;109 (11):4152-7
  20. Qiao, A., A. Khechaduri, R. Kannan Mutharasan, R. Wu, V. Nagpal and H. Ardehali (2013). “MicroRNA-210 decreases heme levels by targeting ferrochelatase in cardiomyocytes.” J Am Heart Assoc 2(2): e000121
  21. Bayeva M,* Khechaduri A,* Wu R, Burke M, Nathaniel B.  Barry H. Sathyamangla P. Prasad N, Ardehali H: ABCB10 Regulates Heme Synthesis by Promoting Mitochondrial Export of δ-Aminolevulinic Acid. Circ Res 2013
  22. Bayeva M, Chang H.C, Wu R, Ardehali H: When less is more: novel mechanisms of iron conservation. Trends Endocrinol Metab. 2013 Aug 12. Trends Endocrinol Metab 24 (11): 569-577
  23. Ichikawa Y*, Ghanefar M*, Bayeva M*, Wu R*, Khechaduri A, Mutharasan K, Naga Prasad S, Ardehali H: JCI 2014 Feb 3; 124(2): 617-30.) (*Contributed equally as first author)
  24. Wu R, Chang HC, Khechaduri A, Chawla K, Tran M, Chai X, Wagg C, Ghanefar M, Jiang X, Bayeva M et al: Cardiac-specific ablation of ARNT leads to lipotoxicity and cardiomyopathy. The JCI 2014, 124(11):4795-4806
  25. Sawicki K, Shang M, Wu R, Chang HC, Khechaduri A, Sato T, Kamide C, Liu T, Ardehali H: Role of heme in cardiovascular physiology and disease. Journal of the American Heart Association 2015, 4(1): e001138
  26. Cheng H*, Wu R* (*Contributed equally as first author) Shang M, Shapiro J, Liu T, Thakur A, Prassad S, Ardehali H: Reduction of mitochondrial, but not cytosolic, iron alleviates cardiac damage during injury.2016 EMBO Molecular Medicine.  2016; 8(3) 247-67
  27. Su L, Knapp M, Wu R. Possible role for HIF-1beta/ARNT in the regulation of vascular function in diabetes and cardiovascular disease. Current Trends in Cardiology. 2017; 1(1)3-4
  28. Rines AK, Chang HC, Wu R et,al.,: Snf1-related Kinase improves cardiac mitochondrial efficiency and decreases mitochondrial uncoupling. Nat Commun. 2017 Aug 30:8:16155
  29. M knapp, Tu X, Wu R: Vascular Endothelial Dysfunction, a Major Mediator in Diabetic Cardiomyopathy. Acta Pharacol Sin, 2019
  30. Q Zhang, M Zheng, CE Betancourt, L Liu, A Sitikov, N Sladojevic, Q Zhao, John H Zhang, JK Liao, R Wu: Blood-brain barrier (BBB) permeability is regulated by MMP3 via the ERK signalling pathway. Oxid Med Cell Longev. 2021 Mar 30;2021: 6655122
  31. Nguyen T, Zheng M, Knapp M, Sladojevic N, Zhang Q, Ai L, Harrison D, Chen A, Sitikov A, Shen L, Gonzalez FJ, Zhao Q, Fang Y, Liao JK, Wu R: Endothelial Aryl Hydrocarbon Receptor Nuclear Translocator Mediates the Angiogenic Response to Peripheral Ischemia in Mice with Type 2 Diabetes Mellitus. Front Cell Dev Biol. 2021 Jun 10;9:691801
  32. Ran X, Zhang Q, Li S, Yu Z, Wan L, Wu B, Wu R, Li S: Tissue Kallikrein Exacerbating Sepsis-Induced Endothelial Hyperpermeability is Highly Predictive of Severity and Mortality in Sepsis. J Inflamm Res. 2021 Jul 15;14:3321-3333
  33. Kumar S, Duan Q, Wu R, Harris E, Su Q: Pathophysiological Communication between Hepatocytes and Non-Parenchymal Cells in Liver Injury from NAFLD to Liver Fibrosis. Adv Drug Deliv Rev. 2021 Jul 16:113869
  34. Ullah K, Wu R: Hypoxia-Inducible Factor Regulates Endothelial Metabolism in Cardiovascular Disease. Front Physiol. 2021 Jul 5;12:670653
  35. Zhang Q, Tan J, Wan L, Chen C, Wu B, Ke X, Wu R, Ran X: Increase in Blood–Brain Barrier Permeability is Modulated by Tissue Kallikrein via Activation of Bradykinin B1 and B2 Receptor-Mediated Signalling. J Inflamm Res. 2021 August 30;14:3321-3333
  36. D. Fan, H. Wu, K. Pan, H. Peng, Wu R: Regenerating Damaged Myocardium: A Review of Stem-Cell Therapies for Heart Failure.2021, Cells, 2021. 10(11)
  37. X. Ran, D.W. Wang, Z. Yu, Wu R, Q. Zhang, Decreased Tissue Kallikrein Levels and the Risk of Ischemic Stroke: A Community-Based Cross-Sectional Study in China, J Inflamm Res 15 (2022) 117-126.
  38. Song Y, Wade H, Zhang B, Xu W, Wu R, Li S, Su Q. Polymorphisms of Fat Mass and Obesity-Associated Gene in the Pathogenesis of Child and Adolescent Metabolic Syndrome. Nutrients. 2023 Jun 6;15(12). doi: 10.3390/nu15122643. Review. PubMed PMID: 37375547; PubMed Central PMCID: PMC10302564.
  39. Wade H, Pan K, Duan Q, Kaluzny S, Pandey E, Fatumoju L, Saraswathi V, Wu R, Harris EN, Su Q. Akkermansia muciniphila and its membrane protein ameliorates intestinal inflammatory stress and promotes epithelial wound healing via CREBH and miR-143/145. J Biomed Sci. 2023 Jun 7;30(1):38. doi: 10.1186/s12929-023-00935-1. PubMed PMID: 37287024; PubMed Central PMCID: PMC10249216.
  40. Ullah K, Li Y, Lin Q, Pan K, Nguyen T, Aniruddhsingh S, Su Q, Sharp W and Wu R: Comparative Analysis of Whole Transcriptome Profiles in Septic Cardiomyopathy: Insights from CLP- and LPS-Induced Mouse Models. Genes 2023;14.
  41. Ullah K, Ai L, Humayun Z and Wu R: Targeting Endothelial HIF2alpha/ARNT Expression for Ischemic Heart Disease Therapy. Biology 2023;12.
  42. X Yang, H Chang, Y Tatekoshi, M Balibegloo, Wu R, C Chen, T Sato, J Shapiro, H Ardehali: SIRT2 inhibition protects against cardiac hypertrophy and heart failure. eLife 2023 September https://doi.org/10.7554/eLife.85571
July 23, 2024
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